A 2. 5-dimensional climate model of intermediate complexity. CLIMBER-2. fully coupled with the GREMLINS 3-D thermo-mechanical ice sheet model is used to simulate the evolution of major Northern Hemisphere ice sheets during the last glacial-interglacial cycle and to investigate the ice sheets responses to both insolation and atmospheric CO<sub>2</sub> concentration. https://www.halohealthcarers.shop/product-category/thumb-supports/